The simple, opposite leaves of Strophanthus luteolus are obovate, elliptic or ovate with entire margins that are faintly hairy, the tips pointed or rounded. The thickish petioles are from 1 mm to 5 mm long. The blades are darker green above than below, with four to six pairs of lateral veins ascending from the midrib showing strongly in its lower part. The net-veining is conspicuous. The latex is clear, white or yellow.
Leaf dimensions are from 2,5 cm to 6,5 cm long and from 1 cm to 3 cm wide (Coates Palgrave, 2002; Pooley, 1998; Germishuizen and Fabian, 1982; iNaturalist).